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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MSH6
All Species:
7.58
Human Site:
T305
Identified Species:
11.9
UniProt:
P52701
Number Species:
14
Phosphosite Substitution
Charge Score:
0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P52701
NP_000170.1
1360
152786
T305
R
K
R
K
R
M
V
T
G
N
G
S
L
K
R
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001113749
1360
152750
T305
R
K
R
K
R
V
V
T
G
N
G
S
L
K
R
Dog
Lupus familis
XP_531814
1283
145094
Y288
S
S
R
P
T
I
W
Y
H
E
T
L
E
W
L
Cat
Felis silvestris
Mouse
Mus musculus
P54276
1358
151058
V305
P
K
R
K
R
A
M
V
A
Q
G
G
L
R
R
Rat
Rattus norvegicus
XP_002726765
1361
151628
A308
P
K
R
K
R
T
V
A
A
H
G
G
L
K
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_419359
1466
164165
S409
E
S
P
I
K
V
P
S
K
R
K
R
G
N
V
Frog
Xenopus laevis
NP_001089247
1340
149481
P288
L
K
R
K
R
G
I
P
D
K
A
S
G
P
K
Zebra Danio
Brachydanio rerio
NP_878280
1369
153213
P307
K
P
I
K
R
K
R
P
T
E
K
P
T
K
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VUM0
1190
133117
N210
S
Y
D
D
I
V
T
N
T
S
N
L
D
E
P
Honey Bee
Apis mellifera
XP_392346
1120
127429
V140
P
E
K
K
R
K
I
V
N
S
F
G
K
K
P
Nematode Worm
Caenorhab. elegans
NP_491163
1186
133609
A206
K
A
V
E
L
E
P
A
E
R
F
D
H
E
S
Sea Urchin
Strong. purpuratus
XP_797647
1335
149141
T287
R
G
S
T
S
T
V
T
P
S
T
N
K
S
A
Poplar Tree
Populus trichocarpa
XP_002320307
1288
142120
V295
K
R
R
R
P
G
D
V
D
Y
D
P
R
T
L
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
O04716
1324
146779
E288
E
V
T
K
S
G
G
E
K
K
S
K
T
D
T
Baker's Yeast
Sacchar. cerevisiae
Q03834
1242
140062
A262
P
S
H
S
Q
P
S
A
T
S
K
S
S
K
F
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
98.3
88.1
N.A.
85.8
86.4
N.A.
N.A.
64.2
66.5
60
N.A.
39
41.2
34.4
48.6
Protein Similarity:
100
N.A.
98.6
91.3
N.A.
92.1
92.8
N.A.
N.A.
75.4
79.9
74.9
N.A.
57.6
58
52.7
66.6
P-Site Identity:
100
N.A.
93.3
6.6
N.A.
46.6
60
N.A.
N.A.
0
33.3
20
N.A.
0
20
0
20
P-Site Similarity:
100
N.A.
100
13.3
N.A.
60
66.6
N.A.
N.A.
20
46.6
26.6
N.A.
20
46.6
20
33.3
Percent
Protein Identity:
36.1
N.A.
N.A.
33.2
29
N.A.
Protein Similarity:
52
N.A.
N.A.
51.4
49.1
N.A.
P-Site Identity:
6.6
N.A.
N.A.
6.6
13.3
N.A.
P-Site Similarity:
26.6
N.A.
N.A.
6.6
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
7
0
0
0
7
0
20
14
0
7
0
0
0
7
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
7
7
0
0
7
0
14
0
7
7
7
7
0
% D
% Glu:
14
7
0
7
0
7
0
7
7
14
0
0
7
14
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
14
0
0
0
7
% F
% Gly:
0
7
0
0
0
20
7
0
14
0
27
20
14
0
0
% G
% His:
0
0
7
0
0
0
0
0
7
7
0
0
7
0
0
% H
% Ile:
0
0
7
7
7
7
14
0
0
0
0
0
0
0
0
% I
% Lys:
20
34
7
54
7
14
0
0
14
14
20
7
14
40
7
% K
% Leu:
7
0
0
0
7
0
0
0
0
0
0
14
27
0
14
% L
% Met:
0
0
0
0
0
7
7
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
7
7
14
7
7
0
7
0
% N
% Pro:
27
7
7
7
7
7
14
14
7
0
0
14
0
7
14
% P
% Gln:
0
0
0
0
7
0
0
0
0
7
0
0
0
0
0
% Q
% Arg:
20
7
47
7
47
0
7
0
0
14
0
7
7
7
27
% R
% Ser:
14
20
7
7
14
0
7
7
0
27
7
27
7
7
14
% S
% Thr:
0
0
7
7
7
14
7
20
20
0
14
0
14
7
7
% T
% Val:
0
7
7
0
0
20
27
20
0
0
0
0
0
0
7
% V
% Trp:
0
0
0
0
0
0
7
0
0
0
0
0
0
7
0
% W
% Tyr:
0
7
0
0
0
0
0
7
0
7
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _